Chance and 'random interference' are essential elements of the creative process for many artists. In life as in art, causal connections are often beyond conscious control: we are acted upon as much as we act. Like gamblers, the artists in You'll Never Know positively welcome, rather than resist, the unpredictable – whether deploying ingenious drawing machines or primitive mark-making incorporating the accidental drips and splashes of ink, paint or mud. In the accompanying essays, a novelist, a scientist and an art historian explore the implications of chance as a factor in gambling, quantum physics and art.